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Objective:To investigate the effect of resourcefulness theory-based nursing on benefit finding and nutritional status of patients with laryngeal carcinoma undergoing radiotherapy after laryngectomy.Methods:A total of 104 patients with laryngeal carcinoma undergoing radiotherapy after laryngectomy were randomly assigned to study group and control group, each of 52 cases. The patients in the control group were given routine nursing intervention, while the study group received resourcefulness theory-based nursing based on the control group. The benefit finding scores, PG-SGA scores as well as other biochemical nutrition index were compared before and after radiotherapy between two groups.Results:Before radiotherapy, the nutritional status and nutritional status scores between study group and control group was not statistically significant ( P>0.05). After radiotherapy, the PG-SGA scores were significantly decreased [(6.14±1.09)points vs. (7.54±1.50)points], body weight index and acceptance scores, worldview scores, personal growth scores, social relationship scores, healthy behavior scores as well as total benefit finding scores were significantly increased in the study group compared to the control group [(21.78±2.08)kg/m 2, 10.37±2.35)points, (13.89±2.83)points, (22.69±5.40)points, (11.20±1.75)points, (12.05±2.35) points, (76.88±7.21) points vs. (20.81±1.94)kg/m 2, (8.20±1.77)points, (12.35±2.24)points, (20.35±4.42)points, (10.23±1.62)points, (9.98±1.64)points, (67.48±5.96)points], the differences was statically significant ( t value was 2.355-7.076, all P<0.05). Conclusion:Resourcefulness theory-based nursing can promote nutritional status and benefit finding of patients with laryngeal carcinoma undergoing radiatherapy after laryngectomy.
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Drug eluting stents are one of the main devices of coronary intervention, which play a therapeutic role through the combination of medical devices. Drug is an important part of the drug eluting stents. The loading method, the type of carrier, drug and carrier interaction and the preparation process of the drug directly affect the drugs release kinetics characteristics of the device and the final treatment. According to the characteristics of the drug coating, drug coated stents can be divided into non-degradable polymers drug coated stents, biodegradable polymers drug coated stents and polymer-free drug eluting stents. This article discussed the stent coating process and drug release kinetics of the three types of drug eluting stent.
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Drug Liberation , Drug-Eluting Stents , Kinetics , Polymers , StentsABSTRACT
Objective To investigate the expression of nuclear factor-κB (NF-κB) and p53 up-regulated modulator of apoptosis (PUMA) in acute lung injury (ALI) induced by severe acute pancreatitis (SAP), and the therapeutic role of proline dithiocarbamate (PDTC). Method SD rats weighed 200～ 250 g were randomly(random number) divided into sham operation group (A group, n = 18), ALI group (B group, n = 18) and PDTC treatment group (C group, n = 18). The model of SAP was eastablished by injecting 1 mL/kg of sodium tauarocholate into the pancreatic capsule of the rats in B group and C group. The model rats in C group were treated with PDTC one hour after modeling. Six rats of each group were sacrificed 6 h,12 h, and 24 hours after modeling. The histopathological changes in lung and pancreas were observed. The levels of NF-κB p65 and PUMA in lung were detected by using Western blotting, and the expressions of bcl-2, bax and caspase-3 mRNA in the lung were detected by using RT-PCR. The lung tissue was taken for examination under transmission electron microscope. TUNEL was used for detection of apoptotic alveolar epithelial cells. Results Six to 24 hours after modeling, the pathological scores in lung of ALI group were significantly higher than those of control group and PDTC group after sodium taurocholate injection ( P ＜ 0.05). The levels of NF-κB p65 and PUMA, and the expressions of bax and caspase3 mRNA in ALI group at different intervals were higher than those in control group and PDTC group ( P ＜ 0.05),whereas the expression of bcl-2 mRNA in ALI group was lower than that in control group and PDTC group ( P ＜0.05). The NF-κB p65 was correlated closely and positively with PUMA ( r= 0.987, P ＜ 0.01). Higher activity of caspase-3 acrtive units was seen in ALI group than that in control group and PDTC group ( P ＜ 0.05). The microvilli disappeared in ALI group 24 hours later. The apoptosis index in ALI group was higher than that in control group and PDTC group ( P ＜ 0.05). Conclusions The apoptosis of alveolar epithelial cells of rats in ALI group is caused by PUMA activated by NF-κB. PDTC treatment can inhibit apoptosis of alveolar epithelial cells of rats in ALI group by inhibiting the activation of NF-κB.
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Objective To study the effect of treating gouty arthritis with Chinese herbal medicines. Methods 64 patients were randomly recruited into a control group and a treatment group, with 32 cases in each group. The treatment group was treated with taking self-made Qingrelishijiedu formula orally and applying Sanhuang powder externally, while the control group was treated with Xinhuang tablets. Results The cure rate of the healing group was 95.45% in comparison with 86.06%in the control group, showing obvious difference (t=3.25, P＜0.05). The level of blood uric acid of both group reduced after the treatment. The level of blood uric acid of the treatment group was (498.2±79.1) μmol/L before the treatment and (338.6±39.9 ) μmol/L after the treatment, contrasting to (492.3 ± 87.5 ) μ mol/L and ( 396.2 ± 67.3 ) μmol/L in the control group. The difference was also statistically obvious (t=3.09, P＜0.05). Conclusion The effect of treating gouty arthritis by Chinese herbal medicine both orally taken and externally applied was better than western medicine exclusively.
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A highly sensitive electrochemical deoxyribonucleic acid(DNA) biosensor based on multi-walled carbon nanotubes(MWNT)/Ag-TiO_2 composite film was developed. The solution containing Ag-TiO_2-MWNT composite was casted on the carbon paste electrode surface to form a robust film, which combine the advantages of the good biocompatibility of Ag-TiO_2 naocomposite and the fine conductivity, as well as the large active surface area of carbon nanotubes. The composite could greatly improve the immobilization capacity of the probe DNA. The morphologies and electrochemistry of the nanocomposite film were investigated by scanning electron microscopy and electrochemical techniques including electrochemical impedance spectroscopy and cyclic voltammetry, respectively. DNA hybridization events were monitored by a label-free method of electrochemical impedance spectroscopy. This label-free electrochemical impedance DNA biosensor showed high sensitivity and selectivity for phosphinothricin acetyltransferase gene sequence assay. The multicomponents films also displayed a high stability during repeated regeneration and hybridization process.
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464 g/kg.Conclusion The nutrients of Salicornia bigelovii Torr.are rich,safe to eat,and worth to develop and utilize.